Abeomics’ proprietary Reporter Cell Lines provide the most advanced system available for screening STATs (STAT1, STAT3, STAT4, STAT5, STAT6), Treg, Th17, TLR, DC-SIGN, Tim-1 and inflammatory pathway mediators. New and unique Leeporter™ Stable Reporter Cell lines include target promoters or upstream response elements for TLRs/RLRs, GPCR, RORs, IL-17A, IL-8, IL-6, p53, Nrf2, Wnt, STAT-1, -3, -4 and -5, NFAT, NF-kB, and more, which drive Renilla Luciferase reporter gene expression. These Luciferase Reporter Cell lines have been validated by extensive functional characterization, illustrate broad working range dynamics, high sensitivity and are designed for high-throughput screening of small molecules. Leeporter™ Luciferase Reporter Cell lines and assay systems are extensively used in Abeomics Drug Discovery Screening Services/ Compound screening services and are also available for direct sale. Abeomics is rapidly adding related modulators, compound libraries and new Reporter Cell Lines to study mechanisms of action and potential development of new cell lines for various disease treatment candidates.
Stable Cell Lines are important tools for protein production, target validation, and functional assays. Abeomics portfolio of stable cell line includes molecules involved in immune modulation, such as, PD-1 cell line, PD-L1 cell line, PD-L2 cell line, CTLA-4 Cell line, ICOS and ICOSL Cell line, TIM3 cell line, Vista cell line etc.