DNA methylation is an epigenetic process that involves the addition of methyl groups to the DNA molecule at many different sites and alters the gene expression by producing lethal and mutagenic lesions. DNA methylation regulates gene expression by the recruitment of proteins involved in gene expression or inhibiting the transcription factors that bind to the DNA. Epigenetic mechanisms like DNA methylation are reversible processes and their inhibition plays a role in the repair of double-strand breaks, the most detrimental type of DNA damage. When damaged DNA is repaired, epigenetic markers are also reconstructed. DNA methylation is believed to be more resilient than other epigenetic markers and aids in maintaining alterations in gene expression. A DNA methylation antibody aids researchers in their understanding of DNA methylation and how illnesses, cell cycle control, and embryonic development are affected by it.
Abeomics Inc. offers well-characterized DNA methylation antibodies that may help scientists and researchers better understand the role of aberrant DNA methylation in diseases like cancer, atherosclerosis, cardiovascular diseases, and nervous disorders. Major methylation antibodies include DNMT3b, DNMT3a, MBD1, MLH1, PMS2 etc.