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  7. Anti-MEK1/2 Antibody

Anti-MEK1/2 Antibody

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Anti-MEK1/2 Antibody

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Product code: 30-2508

Clonality : Polyclonal
Application : WB
Reactivity : Human

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0.05 mg
$355.00 

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  • Antigen Details
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Format : Purified
Amount : 0.05 mg
Isotype : Rabbit IgG
Purification : Purified from rabbit serum by affinity chromatography
Content : 1 mg/ml
Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : MAP2K1
Gene ID : 5604
Alternative Name : MAPKK 1/2, MKK1/2
Immunogen Information : Synthetic peptide (coupled with KLH) derived from aminoacid sequence 33-53 of human MAPK Kinase 1. The immunogen sequence is highly conserved within species (human, mouse, rat, hamster, bovine etc.).
MEK (MAPKK, kinase of mitogen-activated protein kinase) is the medium one of three components of MAP kinase cascade – an important signaling pathway that regulates cell growth and differentiation. Raf (MAPKKK) activates MEK 1 and 2 via phosphorylation of two serine residues (Ser218 and Ser222). Activated MEK 1/2 then acts as a dual Specificity kinase phosphorylating both a threonine and a tyrosine residue on ERK (MAPK, mitogen-activated protein kinase). This phosphorylation of ERK by MEK 1/2 is a critical step in the MAP kinase cascade. Phosphorylated ERK is capable of translocating to the nucleus, where it regulates gene expression by activating transcription factors.
Specificity : The polyclonal antibody reacts with intracellular antigens MEK 1/2. MEK 1 and MEK 2 are integral components of the MAP kinase cascade, an important pathway for cell growth and differentiation.
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Anti-MEK1/2 Antibody

Product code: 30-2508
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