Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Other Kits
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Antibodies
  4. /
  5. Immunology
  6. /
  7. Anti-Smad4 (DPC4) Monoclonal Antibody (Clone: DCS-46)

Anti-Smad4 (DPC4) Monoclonal Antibody (Clone: DCS-46)

Share:

Figure 1. Western blot analysis of SMAD4 using anti-SMAD4 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. Lane 1: rat C6 whole cell lysate, Lane 2: mouse Neuro-2a whole cell lysate.

Anti-Smad4 (DPC4) Monoclonal Antibody (Clone: DCS-46)
Anti-Smad4 (DPC4) Monoclonal Antibody (Clone: DCS-46)

Roll over image to zoom in

   
Figure 1. Western blot analysis of SMAD4 using anti-SMAD4 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. Lane 1: rat C6 whole cell lysate, Lane 2: mouse Neuro-2a whole cell lysate.
Figure 2. Western blot analysis of SMAD4 using anti-SMAD4 antibody (39-1051).Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50μg of sample under reducing conditions. Lane 1: human HepG2 whole cell lysate, Lane 2: human HEK293 whole cell lysate, Lane 3: human COLO-320 whole cell lysate, Lane 4: human THP-1 whole cell lysate.

Product code: 39-1051

Clone name : DCS-46
Clonality : Monoclonal
Application : ICC, WB
Reactivity : Human

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price
100 μg/vial
$550.00 

Add to Wish List

Bulk Order

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • Application Note
  • More
  • Review   (0)
Amount : 100 μg/vial
Isotype : Mouse IgG1
Purification : Ascites
Content : Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage condition : At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Gene : SMAD4
Gene ID : 4089
Uniprot ID : Q13485
Alternative Name : Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; SMAD family member 4; SMAD 4; Smad4; Smad4; Madh4
Immunogen Information : Recombinant human Smad4(DPC4).

SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4(SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.

Western blot : 2-4μg/ml; Immunocytochemistry : 1μg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Monoubiquitinated on Lys-519 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling (By similarity).
There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Recombinant 2020-nCoV S Protein RBD (L452Q, F490S, Mammalian, C-His)

Recombinant 2020-nCoV S Protei...

details-Recombinant 2020-nCoV S Protein RBD (L452Q, F490S, Mammalian, C-His)
Monoclonal Antibody to mouse MD-1 (Clone : MD113)

Monoclonal Antibody to mouse M...

details-Monoclonal Antibody to mouse MD-1 (Clone : MD113)
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human I...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Anti-HSP60 Monoclonal Antibody (Clone : LK1) PerCP

Anti-HSP60 Monoclonal Antibody...

details-Anti-HSP60 Monoclonal Antibody (Clone : LK1) PerCP
Monoclonal Antibody to p53 (Clone BP53-12)

Monoclonal Antibody to p53 (Cl...

details-Monoclonal Antibody to p53 (Clone BP53-12)
Recombinant human CSF1R protein with C-terminal 6×His tag

Recombinant human CSF1R protei...

details-Recombinant human CSF1R protein with C-terminal 6×His tag
Monoclonal Antibody to mouse TIM-4

Monoclonal Antibody to mouse T...

details-Monoclonal Antibody to mouse TIM-4
Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)-Ready to Use

Anti-CDX-2 Monoclonal Antibody...

details-Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)-Ready to Use
CpG ODN (1668), TLR9 ligand (Class B)

CpG ODN (1668), TLR9 ligand (C...

details-CpG ODN (1668), TLR9 ligand (Class B)
ACE2/VERO Stable Cell Line

ACE2/VERO Stable Cell Line

details-ACE2/VERO Stable Cell Line
Anti-CD123 antibody(DM34), Rabbit mAb

Anti-CD123 antibody(DM34), Rab...

details-Anti-CD123 antibody(DM34), Rabbit mAb
VEGFR2 Stable Cell Line-H

VEGFR2 Stable Cell Line-H

details-VEGFR2 Stable Cell Line-H
Sars-CoV-2 Spike Glycoprotein S2  (SF9 cell line)

Sars-CoV-2 Spike Glycoprotein ...

details-Sars-CoV-2 Spike Glycoprotein S2  (SF9 cell line)
Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

Recombinant Human Interleukin-...

details-Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin

Related Products

Mouse Anti-Mouse CD19-APC

Mouse Anti-Mouse CD19-APC

Mouse Monoclonal Antibody to Human CD38 (Clone : 38.H1) (Discontinued)

Mouse Monoclonal Antibody to Human CD38 (Clone : 38.H1) (Discontinued)

Monoclonal Antibody to CD4 (Clone: RPA-T4) FITC Conjugated

Monoclonal Antibody to CD4 (Clone: RPA-T4) FITC Conjugated

New Products

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Anti-TLR2 Antibody (tomaralimab biosimilar)

Anti-TLR2 Antibody (tomaralimab biosimilar)

Recombinant human TLR3 protein with C-terminal mouse Fc tag

Recombinant human TLR3 protein with C-terminal mouse Fc tag

close

Please Login to write a Review !!


close

Anti-Smad4 (DPC4) Monoclonal Antibody (Clone: DCS-46)

Product code: 39-1051
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart