WNT signaling pathways play essential roles in cellular proliferation, differentiation and cell migration during embryonic development. The importance of WNT signaling is indicated by conservation of its molecular components across organisms ranging from nematodes to humans. WNT pathways are classified into canonical WNT/CTNNB or non-canonical (β-catenin-independent) pathways. Canonical WNT/β- catenin signaling is the most studied, and is mediated by nuclear translocation of its central effector CTNNB and Non-canonical WNT signaling occurs independently of CTNNB–TCF/LEF and is stimulated by WNT ligands that bind to a receptor complex of FZD, ROR1/2 or RYK.WNT pathway is implicated in a variety of cancers (Ref.1 and 2). References:
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