PAR4 Stable Cell Line-CHO-K1-Human(Currently Unavailable)
Figure 1: Functional analysis of PAR4 receptor.
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| Amount : | 2 vials |
| Content : | Each Vial contains cells in 45% Ham's F12, 45% FBS, and 10% DMSO |
| Storage condition : | Immediately upon receipt, store in liquid nitrogen. |
| Alternative Name : | Human Recombinant PAR4 Proteinase-activated Receptor Stable Cell Line |
Protease-activated receptor (PAR)-4 is a member of a unique family of GPCRs. The protease-activated receptors (PARs) that are activated by proteolytic cleavage of the N-terminal domain of the receptor reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is a recently identified low-affinity thrombin receptor that plays a pathophysiological role in many types of tissues including the lung. Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors. Culture Medium: Ham's F12, 10% FBS, 400 µg/ml G418
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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