Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Immune-Check Point
        • Kits and Reagents
          • Luciferase reporter assay kits
          • Inhibitor Screening Kit
          • ELISA Kits
          • Molecular Biology Kits
          • Apoptosis Detection kits
          • Flowcytometry staining kits
          • Cell dissociation solutions
          • Western Blot membranes (Quick blots/ Q Blots)
        • Tissue Microarray
        • recmAb™
          • Recombinant Biosimilar Antibodies
          • Recombinant Rabbit Antibodies
          • Recombinant Mouse Antibodies
    • Pathways
        • All-Pathways

          View all pathways

        • interactive-pathways

          View all interactive pathways

    • Custom Service
      • Drug Discovery Screening Services
      • Stable Cell Line Development
      • Protein Production
      • Custom Antibody Development
    • Quick order
      • + Add More..

    • Support
    • Contact us
    • Distributors
    1. Catalog
    2. /
    3. Antibodies
    4. /
    5. Apoptosis
    6. /
    7. Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

    Share:

    Fig 1: Immunohistochemical analysis of Caspase-3 in human colon tissue using Caspase-3 antibody (Clone: ABM1C12) at 5 µg/ml.

    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

    Roll over image to zoom in

       
    Fig 1: Immunohistochemical analysis of Caspase-3 in human colon tissue using Caspase-3 antibody (Clone: ABM1C12) at 5 µg/ml.
    Fig.2: Western blot analysis of Caspase-3. Anti- Caspase-3 (Clone: ABM1C12) was used at 2 µg/ml on Ramos lysate.
    Fig-3 :Immunohistochemical analysis of Caspase-3 in adenocarcinoma of rectum using Caspase-3 antibody (Clone: ABM1C12) at 5 µg/ml.
    Fig-4 :Immunohistochemical analysis of Caspase-3 in human spleen tissue using Caspase-3 antibody (Clone: ABM1C12) at 5 µg/ml.
    Fig-5 :Immunohistochemical analysis of Caspase-3 in squamous cell carcinoma of lungs using Caspase-3 antibody (Clone: ABM1C12) at 5 µg/ml.
    Fig-6 :Immunohistochemical analysis of Caspase-3 in human Small Intestine tissue using Caspase-3 antibody (Clone: ABM1C12) at 10 µg/ml.
    Fig-7 :Immunohistochemical analysis of Caspase-3 in human Tonsil tissue using Caspase-3 antibody (Clone: ABM1C12) at 10 µg/ml.
    Fig-8: Intracellular FLOW cytometric analysis of Caspase 3 (Clone : ABM1C12) inon Jurkat cells using 05 µg/10^6 cells  of antibody. Goat anti-mouse PE conjugate was used as secondary antibody. Green represents isotope control (ABEOMICS), red represents anti-caspase 3 antibody.

    Product code: 10-1003

    Clone name : ABM1C12
    Clonality : Monoclonal
    Application : IHC, FACS, WB
    Reactivity : Human

    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Local delivery areas

    Same-day delivery in San Diego available for the following zip codes:

    92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
    Download TDS MSDS
    Write a review for this product on BioCompare
    Get $20 gift card from Amazon
    Size
    Price

    Available Pack Size(s)

    •   25 µg

    •  100 µg

    • $100.00 

    • $280.00 

    Add to Wish List

    Bulk Order

    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Download TDS MSDS

    • Product Info
    • Antigen Details
    • Description
    • Application Note
    • More
    • Review   (0)
    Format : Purified
    Amount : 100 µg
    Isotype : Mouse IgG1 Kappa
    Purification : Protein G Chromatography
    Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
    Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : CASP3
    Gene ID : 836
    Uniprot ID : P42574
    Alternative Name : Casp3, Cpp32
    Immunogen Information : Full length recombinant Caspase-3 protein was used as the immunogen for this antibody.

    Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.

    Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5-10 µg/ml, FACS analysis: 0.5-1 µg/10^6 cells

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cytoplasm
    Post transnational modification: S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
    Tissue Specificity: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
    BioGrid: 107286. 102 interactions.
    There are currently no product reviews
    Write a review on this product!

    Customers who purchased this product also purchased

    TLR2 Mouse

    TLR2 Mouse

    details-TLR2 Mouse
    SARS-CoV-2 (2019-nCoV) Spike S1 (N439K) His Tag Protein

    SARS-CoV-2 (2019-nCoV) Spike S...

    details-SARS-CoV-2 (2019-nCoV) Spike S1 (N439K) His Tag Protein
    Recombinant Human ACE2 His and FLAG Tag

    Recombinant Human ACE2 His and...

    details-Recombinant Human ACE2 His and FLAG Tag
    CD200 Mouse

    CD200 Mouse

    details-CD200 Mouse
    Anti-CD57 Monoclonal Antibody (Clone:TB01)

    Anti-CD57 Monoclonal Antibody ...

    details-Anti-CD57 Monoclonal Antibody (Clone:TB01)
    Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

    Monoclonal Antibody to Human I...

    details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
    Polyclonal Antibody to Beta Tubulin

    Polyclonal Antibody to Beta Tu...

    details-Polyclonal Antibody to Beta Tubulin
    SARS-CoV-2 Neutralizing Antibodies Detection Kit

    SARS-CoV-2 Neutralizing Antibo...

    details-SARS-CoV-2 Neutralizing Antibodies Detection Kit
    Peroxidase conjugated Goat anti Mouse IgG (H+L)

    Peroxidase conjugated Goat ant...

    details-Peroxidase conjugated Goat anti Mouse IgG (H+L)
    SARS-CoV-2 (2019-nCoV) Spike S1, Southern California mutant (S13l / W152C / L452R) His Tag Protein

    SARS-CoV-2 (2019-nCoV) Spike S...

    details-SARS-CoV-2 (2019-nCoV) Spike S1, Southern California mutant (S13l / W152C / L452R) His Tag Protein
    SARS-CoV-2 (2019-nCoV) Spike S1 South African Mutant (K417N / E484K / N501Y) His Tag Protein

    SARS-CoV-2 (2019-nCoV) Spike S...

    details-SARS-CoV-2 (2019-nCoV) Spike S1 South African Mutant (K417N / E484K / N501Y) His Tag Protein
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

    Monoclonal antibody to Human P...

    details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    CTF1 Human

    CTF1 Human

    details-CTF1 Human

    Most viewed Products

    Recombinant Human Thioredoxin-Like 4A

    Recombinant Human Thioredoxin-Like ...

    details-Recombinant Human Thioredoxin-Like 4A
    Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

    Monoclonal Antibody to Human IL-1be...

    details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
    NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

    NF-kB Leeporter™ Luciferase Repor...

    details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

    Monoclonal antibody to Human PD-L1 ...

    details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Polyclonal Antibody to Beta actin

    Polyclonal Antibody to Beta actin

    details-Polyclonal Antibody to Beta actin
    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

    Monoclonal Antibody to Caspase-3 (P...

    details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
    Monoclonal Antibody to GAPDH (Clone: ABM22C5)

    Monoclonal Antibody to GAPDH (Clone...

    details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
    Monoclonal antibody to B7-H4 (Clone: ABM53A6)

    Monoclonal antibody to B7-H4 (Clone...

    details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
    Polyclonal Antibody to Beta Tubulin

    Polyclonal Antibody to Beta Tubulin

    details-Polyclonal Antibody to Beta Tubulin
    Peroxidase conjugated Goat anti Mouse IgG (H+L)

    Peroxidase conjugated Goat anti Mou...

    details-Peroxidase conjugated Goat anti Mouse IgG (H+L)

    Related Products

    Polyclonal antibody to m BID

    Polyclonal antibody to m BID

    Polyclonal antibody to Bcl-2

    Polyclonal antibody to Bcl-2

    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

    Mouse Monoclonal Antibody to p53 (Clone : 2D2G6)(Discontinued)

    close

    Please Login to write a Review !!


    close

    Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

    Product code: 10-1003
    *specify in mg or ml

    Abeomics Logo

    Antibodies & Engineered Cell Lines™

    Tel : 858-263-4982

    Fax : 858-247-7052

    Email : support@abeomics.com

    Connect with Us

    • Facebook
    • Twitter
    • Linkedin
    • YouTube

    Products

    • Antibodies
    • Cell Lines
    • Ligands and Inhibitors
    • Recombinant Proteins
    • Immune-Check Point
    • Kits and Reagents
    • Tissue Microarray
    • recmAb™

    Services

    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development

    Quick order

    + Add More..

    Newsletter

    Posters and Flyers

    © 2022 Abeomics. All rights reserved.
    • Blog
    • Sitemap
    • Terms
    • Privacy Policy
    • Legal
    • Email unsubscribe

    Item added to cart successfully

    No cart item available
    Continue shopping View Cart