5-HT2A Stable Cell Line-CHO-K1-Human
|Amount :||2 vials|
|Content :||Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO|
|Storage condition :||Immediately upon receipt, store in liquid nitrogen.|
|Alternative Name :||Human Recombinant 5-HT2A Serotonin Receptor Stable Cell Line|
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal, and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al., 1994). 5-HT2A which couples to Gq/11 is expressed throughout the central nervous system in the neocortex and olfactory tubercle. 5-HT2A receptor agonists may have important clinical value in the treatment of various disorders, such as depression, anxiety, bipolar disorder, and schizophrenia. The cloned human 5-HT2Aexpressing cell line is generated in the CHO-K1 host.
Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: Ham's F12, 10% FBS, 400µg/ml G418
For Research Use Only. Not for use in diagnostic/therapeutics procedures.