Anti-CD134, Mouse (OX40) Monoclonal Antibody(Clone: OX-86) BSA/Azide Free
|Amount :||100 µg|
|Isotype :||Rat IgG1, kappa|
|Content :||1.0 mg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS|
|Storage condition :||Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.|
|Gene ID :||22163|
|Uniprot ID :||P47741|
|Alternative Name :||CD134; IMD16; Lymphoid activation antigen (ACT35); OX40 cell surface antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4); Txgp1l|
|Immunogen Information :||Purified recombinant Mouse OX-40 antigen|
CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.
Does not block binding of OX40L; Flow Cytometry (0.5-1ug/million cells in 0.1ml); Immunofluorescence (1-2ug/ml);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.