Anti-CD267 / TACI -Biotin Conjugated Monoclonal Antibody (Clone:1A1)
Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD267 (1A1) Biotin antibody (concentration in sample 1.67 μg/ml, streptavidin APC).
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG2a kappa |
| Purification : | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
| Content : | Concentration: 1 mg/ml Content: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The rat monoclonal antibody 1A1 recognizes an extracellular epitope of CD267 / TACI, a 32 kDa type III transmembrane protein expressed by B cells and possibly by some activated T cells.
CD267 / TACI (Transmembrane Activator Calcium modulator and cyclophilin ligand Interactor), a TNFR superfamily transmembrane protein, is expressed on B cells (predominantly on CD27+ memory cells), multiple myeloma cells and B cell chronic lymphocytic leukemia (B-CLL). Its triggering leads to activation of the transcription factors NFAT, AP1, and NF-kappa-B. It plays a crucial role in humoral immunity. Mutations in CD267 are associated with common variable immunodeficiency and IgA deficiency.
Flow cytometry: Recommended dilution: 1-5 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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