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    7. Anti-Collagen Type IV Monoclonal Antibody (Clone:IHC549)

    Anti-Collagen Type IV Monoclonal Antibody (Clone:IHC549)

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    Figure 1: Immunohistochemical analysis of Collagen Type IV (Clone: IHC549) on Liver

    Anti-Collagen Type IV Monoclonal Antibody (Clone:IHC549)

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    Product code: 44-1021

    Clone name : IHC549
    Clonality : Monoclonal
    Application : IHC
    Reactivity : Human

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    •   0.1 ml

    •  0.5 ml

    • $300.00 

    • $513.00  $410.40 

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    • Product Info
    • Antigen Details
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    Format : Purified
    Amount : 0.5 ml
    Isotype : Mouse IgG1, kappa
    Purification : Protein A/G Chromatography
    Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
    Storage condition : Store at 2°C - 8°C. Do not freeze.
    Gene : COL4A4
    Gene ID : 1286
    Uniprot ID : P53420
    Alternative Name : COL4A4
    Immunogen Information : Human Placenta

    Collagen Type IV is a primary component in the basal lamina that is used as a marker to observe the presence of the lamina and examine its structure. In addition to the epithelial basal lamina, Anti-Collagen Type IV stains mesenchymal components. It is useful for identifying soft tissue cancers including schwannomas and leiomyomas. Anti-Collagen Type IV frequently reacts with these tissues after becoming well-differentiated and malignant. The use of Anti-Collagen Type IV produces more reliable results than non-specific silver reticulum stains when investigating the vascular elements of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma.

    Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Secreted
    Post transnational modification: The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
    Tissue Specificity: Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. Highest levels of expression of alpha 4 type IV collagen are detected in kidney, calvaria, neuroretina and cardiac muscle. Lower levels of expression are observed in brain, lung and thymus, and no expression is detected in choroid plexus, liver, adrenal, pancreas, ileum or skin.
    BioGrid: 107683. 1 interactions.
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    Anti-Collagen Type IV Monoclonal Antibody (Clone:IHC549)

    Product code: 44-1021
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