Anti-Glypican-3 Monoclonal Antibody (Clone:IHC405)(Discontinued)

Product code: 44-1123

Clone name : IHC405
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Format : Purified
Amount : 1 ml
Purification : Protein A/G Chromatography
Storage condition : Store at 2°C - 8°C.
Gene : GPC3
Gene ID : 2719
Uniprot ID : P51654
Alternative Name : GPC3, OCI5, GTR2-2, Intestinal protein OCI-5, MXR7

Glypican-3 (GPC3) is a GPI-archored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumor marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and WilmsÂ’ tumor. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, which is higher than cirrhotic liver or liver with focal lesions including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumors of certain subtypes, such as yolk sac tumors and choriocarcinoma, and in embryonal tumors.

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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