Anti-Glypican-3 Monoclonal Antibody (Clone:IHC405)
|Amount :||1 ml|
|Purification :||Protein A/G Chromatography|
|Storage condition :||Store at 2°C - 8°C.|
Glypican-3 (GPC3) is a GPI-archored proteoglycan involved in cell division and growth regulation. Glypican-3 is a useful tumor marker, and its expression has been shown to be upregulated in hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor. Patients with HCC have presented elevated levels of GPC3 in the neoplastic liver tissues and serum, which is higher than cirrhotic liver or liver with focal lesions including those with hepatic adenoma and dysplastic nodules. Glypican-3 is also overexpressed in testicular germ cell tumors of certain subtypes, such as yolk sac tumors and choriocarcinoma, and in embryonal tumors.
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.