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  7. Anti-GRAP2 APC (Clone : UW40)

Anti-GRAP2 APC (Clone : UW40)

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Figure 1 : Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human GRAP2(UW40) APC antibody (concentration in sample 1,7 µg/ml).

Anti-GRAP2 APC (Clone : UW40)
Anti-GRAP2 APC (Clone : UW40)

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Figure 1 : Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human GRAP2(UW40) APC antibody (concentration in sample 1,7 µg/ml).
Figure 2 : Separation of lymphocytes stained using anti-human GRAP2 (UW40) APC antibody (concentration in sample 1,7 µg/ml, red-filled) from lymphocytes stained using mouse IgG2a isotype control (MOPC-173) APC antibody (concentration in sample 1,7 µg/ml, same as GRAP2 APC concentration, black-dashed) in flow cytometry analysis (intracellular staining) of peripheral blood.

Product code: 30-2528

Clone name : UW40
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : APC

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0.1 mg
$443.00 

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  • Antigen Details
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Amount : 0.1 mg
Isotype : Mouse IgG2a
Purification : The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Content : 0.1 mg/ml
Formulation : Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : GRAP2
Gene ID : 9402
Alternative Name : GADS, GRID, GRAP-2, GrbX,GRB2 related adaptor protein 2
Immunogen Information : GST-fusion human GRAP2/GADS protein
GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
Specificity : The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
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Anti-GRAP2 APC (Clone : UW40)

Product code: 30-2528
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