Anti-HPV16 E2 (Human Papilloma Virus 16) Monoclonal Antibody(Clone: TVG 261)
Fig. 1: SDS-PAGE Analysis Purified Mouse Monoclonal Antibody HPV16 E2 (Human Papilloma Virus 16). Confirmation of Purity and Integrity of Antibody.
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| Alternative Name : | HPV16 regulatory protein E2; Human papilloma virus 16 E2; Human papilloma virus 16 regulatory protein E2; Human papillomavirus type 16 E2; Human papillomavirus type 16 regulatory protein E2; Regulatory protein E2 |
| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Immunogen Information : | Raised against Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2 |
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a strain that is responsible for the largest number of cases of cervical cancers linked to the family. HPV16E1 and HPV16E2 are proteins that are involved in the regulation of viral DNA replication and are important for infected cell homeostasis. HPV16E2 specifically regulates the expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region, possibly involving interactions with nuclear hormone receptors. Integration of the HPV genome into the host DNA usually disrupts the HPV16E2 gene open reading frames, resulting in an overexpression of E6 and E7 genes, an event that may lead to the malignant transformation of cervical cancer. HPV16E2 is also able to induce apoptotic cell death via two pathways: the first throµgh the binding of p53 and the second throµgh the binding of the viral genome.
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
Western Blot (1-2µg/ml); Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
