Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Antibodies
  4. /
  5. Cell Signalling
  6. /
  7. Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)

Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)

Share:

Figure1 : Mouse Anti-Hsp90 beta Antibody [Hyb-K3701] used in Immunohistochemistry (IHC) on Mouse inflamed colon

Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)
Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)
Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)

Roll over image to zoom in

   
Figure1 : Mouse Anti-Hsp90 beta Antibody [Hyb-K3701] used in Immunohistochemistry (IHC) on Mouse inflamed colon
Figure 2 :  Mouse Anti-Hsp90 beta Antibody [Hyb-K3701] used in Immunohistochemistry (IHC) on Human colon carcinoma
Figure 3 :  Mouse Anti-Hsp90 beta Antibody [Hyb-K3701] used in Western Blot (WB) on Human Cell lysates

Product code: 42-1245

Clone name : Hyb-K3701
Clonality : Monoclonal
Application : ELISA, IHC, WB
Reactivity : Mouse, Human
Conjugate : APC

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS
Write a review for this product on BioCompare
Get $20 gift card from Amazon

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • Application Note
  • More
  • Review   (0)
Amount : 100 µg
Isotype : Mouse IgM
Purification : Protein G Purified
Content : PBS pH7.2, 50% glycerol, 0.09% sodium azide
Storage condition : Store the antibody at 4°C
Gene : HSP90AB1
Gene ID : 3326
Uniprot ID : P08238
Alternative Name : HSP90AB1, HSP90B, HSPC2, HSPCB
Immunogen Information : Recombinant human HSP90beta; Specificity mapped to amino acids 185-335

HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of HSP90 are expressed in the cytosolic compartment. Despite the similarities, HSP90 alpha exists predominantly as a homodimer while HSP90 beta exists mainly as a monomer. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. Furthermore, HSP90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively. HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling. The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase. When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation. In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immunoadsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function.

WB (1:1000), IHC (1:3000); optimal dilutions for assays should be determined by the user.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Melanosome, Nucleus, Secreted, Cell membrane
Post transnational modification: Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.
BioGrid: 109558. 383 interactions.
There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Anti-IL6R Antibody (tocilizumab biosimilar) (MRA)

Anti-IL6R Antibody (tocilizuma...

details-Anti-IL6R Antibody (tocilizumab biosimilar) (MRA)
Anti-PRKAR2A Monoclonal Antibody (Clone:Hs-36)

Anti-PRKAR2A Monoclonal Antibo...

details-Anti-PRKAR2A Monoclonal Antibody (Clone:Hs-36)
Recombinant 2019-nCoV S Protein RBD (L452R, Mammalian, C-His)

Recombinant 2019-nCoV S Protei...

details-Recombinant 2019-nCoV S Protein RBD (L452R, Mammalian, C-His)
Anti-Mouse CD2 FITC (Clone : RM2-5)

Anti-Mouse CD2 FITC (Clone : R...

details-Anti-Mouse CD2 FITC (Clone : RM2-5)
Rat IgG2a Isotype Control PE Antibody (Clone : S193)

Rat IgG2a Isotype Control PE A...

details-Rat IgG2a Isotype Control PE Antibody (Clone : S193)
Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)-Ready to Use

Anti-CTLA-4 Monoclonal Antibod...

details-Anti-CTLA-4 Monoclonal Antibody (Clone:IHC004)-Ready to Use
Anti-Podoplanin Monoclonal Antibody (Clone:IHC650)-Ready to Use

Anti-Podoplanin Monoclonal Ant...

details-Anti-Podoplanin Monoclonal Antibody (Clone:IHC650)-Ready to Use
Recombinant Sars-Cov-2 (COVID-19/2019-nCov) Spike S1 Protein

Recombinant Sars-Cov-2 (COVID-...

details-Recombinant Sars-Cov-2 (COVID-19/2019-nCov) Spike S1 Protein
GKN3P Recombinant Protein

GKN3P Recombinant Protein

details-GKN3P Recombinant Protein
SARS Spike Protein (306-527)

SARS Spike Protein (306-527)

details-SARS Spike Protein (306-527)
Anti-Cytokeratin 8 Monoclonal Antibody (Clone:C-51)

Anti-Cytokeratin 8 Monoclonal ...

details-Anti-Cytokeratin 8 Monoclonal Antibody (Clone:C-51)
Anti-Human CTLA-4 (Ipilimumab) – Fc Muted™ Biotin

Anti-Human CTLA-4 (Ipilimumab)...

details-Anti-Human CTLA-4 (Ipilimumab) – Fc Muted™ Biotin
Anti-Human CD41/CD61 (PAC-1 epitope) PE (Clone : PAC-1)

Anti-Human CD41/CD61 (PAC-1 ep...

details-Anti-Human CD41/CD61 (PAC-1 epitope) PE (Clone : PAC-1)
AURKA Recombinant Protein

AURKA Recombinant Protein

details-AURKA Recombinant Protein

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin

Related Products

Polyclonal Antibody to FAK (Phospho-Tyr397)

Polyclonal Antibody to FAK (Phospho-Tyr397)

Anti-HSP40, YDJ1 Monoclonal Antibody (Clone : 2A7.H6) - PE/ATTO 594(Discontinued)

Anti-HSP40, YDJ1 Monoclonal Antibody (Clone : 2A7.H6) - PE/ATTO 594(Discontinued)

Anti-HSP90 Monoclonal Antibody (Clone : H9010) - ATTO 655(Discontinued)

Anti-HSP90 Monoclonal Antibody (Clone : H9010) - ATTO 655(Discontinued)

New Products

Recombinant Human Paralemmin-3

Recombinant Human Paralemmin-3

Recombinant Mouse FGL1 (C-hFc)

Recombinant Mouse FGL1 (C-hFc)

Anti-c-Myc tag Purified

Anti-c-Myc tag Purified

close

Please Login to write a Review !!


close

Anti-HSP90 beta Monoclonal Antibody (Clone : Hyb-K3701) APC(Discontinued)

Product code: 42-1245
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart