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  7. Anti-Human CD172ab Antibody (Clone : SE5A5)

Anti-Human CD172ab Antibody (Clone : SE5A5)

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Figure 1 : Flow cytometry analysis (surface staining) of human peripheral blood cells with anti-human CD172a/b (SE5A5) purified, GAM-APC.

Anti-Human CD172ab Antibody (Clone : SE5A5)

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Product code: 30-2632

Clone name : SE5A5
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$364.00 

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  • Antigen Details
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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Content : 1 mg/ml
Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Alternative Name : PTPNS1, BIT, MFR, SIRPA, SHPS1, SIRPB1
Immunogen Information : NIH-3T3 / human CD172a cell line
CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells. Extracellular part of CD172b is 90% identical to that of CD172a, but unlike CD172, it has dramatically reduced intracellular domain.
Specificity : The mouse monoclonal antibody SE5A5 recognizes a common extracellular epitope on human CD172a and CD172b antigens (approx. 90 kDa and approx. 50 kDa, respectively), although its reactivity with CD172a is higher.
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Anti-Human CD172ab Antibody (Clone : SE5A5)

Product code: 30-2632
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