Anti-Human CTLA-4 (Ipilimumab) Biotin
|Amount :||100 µg|
|Isotype :||Human IgG1k|
|Content :||Concentration : 0.5 mg/ml
This Biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
|Storage condition :||This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.|
|Alternative Name :||CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3|
|Immunogen Information :||Human CTLA-4|
Expression Host : HEK-293
This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Ipilimumab. Ipilimumab binds to Human CTLA-4. This product is for research use only.
Cytotoxic T-lymphocyteassociated antigen 4 (CTLA-4) is a protein receptor that serves as an immune checkpoint and down-regulates the immune system. CTLA-4 is constitutively expressed in regulatory T cells but is only upregulated in conventional T cells following activation. Many cancers, including Melanoma, are associated with CTLA-4 upregulation because the bodys ability to recognize and destroy cancer cells is hampered by an inhibitory mechanism. Ipilimumab targets CTLA-4 and works by turning off this inhibitory mechanism and, thus, enhances the bodys own immune response against cancer cells.2 Emerging research suggests that combined blockade of PD-1 and CTLA-4, with Nivolumab and Ipilimumab respectively, could produce greater antitumor activity than blockade of either pathway alone.1 This cost-effective, research-grade Anti-Human CTLA-4 (Ipilimumab) utilizes the same variable regions from the therapeutic antibody Ipilimumab making it ideal for research projects.
The suggested concentration for Ipilimumab biosimilar antibody for staining cells in flow cytometry is <= 1.0 µg per 106 cells in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.ELISA
For Research Use Only. Not for use in diagnostic/therapeutics procedures.