Anti-TNF-alpha Monoclonal Antibody (Clone:MAb11)

TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis.

Flow Cytometry Application note:intracellular staining
Immunohistochemistry (frozen sections) Application note:paraformaldehyde-fixed, saponin-treated frozen tissue sections
Immunocytochemistry ELISA Biotinylated MAb11 can be used as a detection antibody in combination with capture antibody MAb1 Functional Application neutralization

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
Tissue Specificity:	Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
BioGrid:	112979. 269 interactions.

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