BB1 Stable Cell Line-CHO-K1-Human
Figure 1: Functional analysis of BB1 receptor.
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| Amount : | 2 vials |
| Content : | Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO |
| Storage condition : | Immediately upon receipt, store in liquid nitrogen. |
| Alternative Name : | Human Recombinant BB1 Bombesin Receptor Stable Cell Line |
The bombesin receptor family is a member of the G protein-coupled receptor superfamily and consists of three subtypes of receptors: BB1 (neuromedin B receptor), BB2 (gastrin-releasing peptide receptor), and BB3. These receptors are widely distributed in mammals especially in the CNS and gastrointestinal tract and have numerous effects both physiologically and in pathologic processes including having an autocrine growth action on normal tissues and tumors; potent CNS effects (satiety, circadian rhythm, various behaviors); and potent effects in the immune, gastrointestinal, respiratory and urogenital systems.The human BB1 receptor has a greater than 100-fold higher affinity for neuromedin B than gastrin-releasing peptide. Interaction of ligand and BB1 activates the G alpha q/11 pathway and increase the intracellular calcium concentration. The BB1-expressing stable cell line was made in CHO-K1 host cell and optimized for calcium assays.
Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: Ham's F12, 10% FBS, 400 µg/ml G418
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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