Biotinylated Recombinant Human Polymeric Immunoglobulin Receptor/PIgR (C-His)
|Amount :||25 µg|
|Content :||0.2mg/ml in sterile PBS, pH7.6|
|AA sequence :||Biotinylated Recombinant Human Polymeric Immunoglobulin Receptor is produced by Human 293 Cells. The target gene encoding K19-R639 is expressed with a 8His tag at the C-terminus.|
|Alternative Name :||Polymeric Immunoglobulin Receptor; PIgR; Poly-Ig Receptor; Hepatocellular Carcinoma- Associated Protein TB6; PIGR|
Source : Human 293 Cells;
Polymeric Immunoglobulin Receptor (pIgR) is a type I transmembrane glycoprotein. pIgR is expressed by secretory epithelial cells with five Ig-like domains in the extracellular region, and transfer to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs and separates the extracellular (known as the secretory component) from the transmembrane segment.