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  7. G alpha 15 Stable Cell Line-MTLR-CHO-K1-Human(Currently Unavailable)

G alpha 15 Stable Cell Line-MTLR-CHO-K1-Human(Currently Unavailable)

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Figure 1: Functional analysis of motilin receptor.

G alpha 15 Stable Cell Line-MTLR-CHO-K1-Human(Currently Unavailable)

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Product code: 14-6155ACL

Application : Functional Assay
Reactivity : Human

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Amount : 2 vials
Content : Each Vial contains cells in 45% culture medium, 45% FBS, 10% DMSO
Storage condition : Immediately upon receipt, store in liquid nitrogen.
Alternative Name : Human Recombinant Motilin Receptor Stable Cell Line
The motilin receptor (MTLR) represents a clinically useful pharmacological target, as agonists binding to the MTLR have gastroprokinetic properties. Motilin is a 22 amino acid peptide that potently stimulates gastrointestinal contractility. The biological effects of motilin are mediated by a Gq-coupled seven transmembrane protein, currently termed motilin receptor (MR) that shares significant sequence similarity with the ghrelin receptor. The motilin receptor is also activated by the antibiotic erythromycin; this interaction appears to mediate some of the gastrointestinal side effects of erythromycin. Although motilides (non-antibiotic derivatives of erythromycin) such as ABT-229 have been investigated for treatment of diabetic gastroporesis, the effectiveness has been limited by tachyphylaxis (decreased response to ligand) resulting from receptor downregulation. Agonists of the motilin receptor with reduced densensitization activity remain a potential treatment for disorders of gastric motility.

Application: Screen for antibodies through Flow Cytometry, Immunocytochemistry or Western blotting and analyzing receptors.
Culture Medium: Ham's F12, 10% FBS, 400 µg/ml G418, 100 µg/ml Hygromycin B

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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G alpha 15 Stable Cell Line-MTLR-CHO-K1-Human(Currently Unavailable)

Product code: 14-6155ACL
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