Anti-Desmin Monoclonal Antibody (Clone: DE-U-10)

Figure 1: Anti-Desmin monoclonal antibody(39-1031). IHC(P): Rat Cardiac Muscle Tissue.

Anti-Desmin Monoclonal Antibody (Clone: DE-U-10)

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Figure 1: Anti-Desmin monoclonal antibody(39-1031). IHC(P): Rat Cardiac Muscle Tissue.

Figure 2: Anti-Desmin monoclonal antibody(39-1031). Western blotting: Lanes: Anti Desmin(39-1031) at 0.5 ug/ml.
Lane 1: Rat Skeletal Muscle Tissue Lysate at 50ug, Lane 2: Rat Cardiac Muscle Tissue Lysate at 50ug, Lane 3: Mouse Skeletal Muscle Tissue Lysate at 50ug, Lane 4: Mouse Cardiac Muscle Tissue Lysate at 50ug. Predicted band size: 53 kDa: Observed band size: 53 kDa.

Product code: 39-1031

Clone name :	DE-U-10
Clonality :	Monoclonal
Application :	WB
Reactivity :	Human

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Download TDS MSDS

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Download TDS MSDS

Amount :	100 μg/vial
Isotype :	Mouse IgG1
Purification :	Ascites
Content :	Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage condition :	At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.


Gene :	Des
Gene ID :	64362
Uniprot ID :	P48675
Alternative Name :	Desmin; Des
Immunogen Information :	Desmin from pig stomach.

Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball(1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al.(1989) localized the gene to 2q35. Desmin mutation responsible for idiopathic dilated cardiomyopathy.

Western blot : 2μg/ml; Immunohistochemistry(Paraffin-embedded Section) : 2-4μg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Cytoplasm, Cell membrane, Nucleus
Post transnational modification:	Phosphorylation at Ser-7, Ser-28 and Ser-32 by CDK1, phosphorylation at Ser-60 by AURKB and phosphorylation at Thr-76 by ROCK1 contribute to efficient separation of desmin intermediate filaments during mitosis.