Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Product code: 10-7599

Clone name : ABM5F25
Clonality : Monoclonal
Application : IHC, FACS, WB
Reactivity : Human

Shipping Info:

Order now and get it on Tuesday October 08, 2024

Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

Add to Wish List

Shipping Info:

Order now and get it on Tuesday October 08, 2024

Same day delivery FREE on San Diego area orders placed by 1.00 PM


Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : CD274
Gene ID : 29126
Uniprot ID : Q9NZQ7
Alternative Name : CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Immunogen Information : A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitates apoptosis of activated T cells, and induces T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.

FACS analysis: 0.5-1 µg/10^6 cells; Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis: 5-10 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endomembrane system
Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
BioGrid: 118891. 48 interactions.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products