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    7. Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

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    Fig:1- Cell Surface flow analysis of PD-L1 in 3 day-PHA treated human PBMC cells using 1 µg/10^6 cells of PD-L1 antibody (Clone: ABM5F25). Green represents isotype control; red represents anti-PD-L1 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.

    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

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    Fig:1- Cell Surface flow analysis of PD-L1 in 3 day-PHA treated human PBMC cells using 1 µg/10^6 cells of PD-L1 antibody (Clone: ABM5F25). Green represents isotype control; red represents anti-PD-L1 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
    Fig-2: Cell surface flow analysis of PD-L1 in CHO-PD-L1 transfected cell line using 0.5 µg/10^6 cells of PD-L1 antibody (Clone: ABM5F25). Green represents isotype control; red represents anti-PD-L1 antibody. Goat anti-mouse PE conjugate was used as secondary antibody.
    Fig-3: Western blot analysis of PDL1. Anti-PD-L1 antibody (Clone: ABM5F25) was tested at 0.5 µg/ml on Recombinant lysate.
    Fig-4: Western blot analysis of PDL1. Anti-PD-L1 antibody (Clone: ABM5F25) was tested at 2 µg/ml on (1) Daudi and (2) HepG2 lysates.
    Fig-5: Immunohistochemical analysis of PD-L1 in Hodkin's Lymphoma tissue using PD-L1 antibody (Clone: ABM5F25) at 5 µg/ml.
    Fig-6: Western blot analysis of PDL1. Anti-PD-L1 antibody (Clone: ABM5F25) was tested at 0.5 µg/ml on (1) U87 and (2) THP1 lysates.

    Product code: 10-7599

    Clone name : ABM5F25
    Clonality : Monoclonal
    Application : IHC, FACS, WB
    Reactivity : Human

    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Local delivery areas

    Same-day delivery in San Diego available for the following zip codes:

    92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
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    Price

    Available Pack Size(s)

    •   25 µg

    •  100 µg

    • $100.00 

    • $280.00 

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    Shipping Info:

    Order now and get it on Tuesday July 05, 2022

    Same day delivery FREE on San Diego area orders placed by 1.00 PM

    Download TDS MSDS

    • Product Info
    • Antigen Details
    • Description
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    • Review   (0)
    Format : Purified
    Amount : 100 µg
    Isotype : Mouse IgG2b Kappa
    Purification : Protein G Chromatography
    Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
    Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : CD274
    Gene ID : 29126
    Uniprot ID : Q9NZQ7
    Alternative Name : CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Immunogen Information : A partial length recombinant protein of PD-L1 (amino acid 13-224) was used as the immunogen for this antibody.

    PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitates apoptosis of activated T cells, and induces T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.

    FACS analysis: 0.5-1 µg/10^6 cells; Western blot analysis: 2-4 µg/ml; Immunohistochemical analysis: 5-10 µg/ml

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Endomembrane system
    Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
    Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
    BioGrid: 118891. 48 interactions.
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    Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

    Product code: 10-7599
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