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    7. Monoclonal Antibody to Rat C5aR (clone: R63)

    Monoclonal Antibody to Rat C5aR (clone: R63)

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    Monoclonal Antibody to Rat C5aR (clone: R63)

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    Product code: 10-3564

    Clone name : R63
    Clonality : Monoclonal
    Application : IHC-Fr, ELISA, FACS, WB, IF
    Reactivity : Rat

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    Size
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    Available Pack Size(s)

    •   1.0 mg

    •  500 µg

    • $2,100.00 

    • $1,500.00  $1,200.00 

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    • Product Info
    • Antigen Details
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    Amount : 500 µg
    Isotype : Mouse IgG1
    Content : 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
    Storage condition : Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year.
    Gene : C5ar1
    Gene ID : 113959
    Uniprot ID : P97520
    Alternative Name : C5a-R, C5aR, CD88
    Immunogen Information : RBH-2H3 cells transfected with rat C5aR gene

    The monoclonal antibody R63 reacts with the rat receptor for C5a (CD88). The rat anaphylatoxin C5a, a 77-amino acid glycopolypeptide generated by proteolytic cleavage of C5, is one of the most potent inflammatory chemo attractants and interacts with two C5a receptors, C5aR and C5L2.- Most of the C5a effects are mediated through C5aR. C5aR is known to be crucial in the initiation of acute inflammatory responses. C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by leukocytes such as neutrophils, eosinophils, basophils, monocytes, dendritic cells and mast cells. C5aR can be expressed on both immune and non-immune cells. The latter, include vascular endothelial cells, cardiomyocytes and bronchial epithelial cells. Signaling of C5aR involves intracellular calcium mobilization and activation of among others protein kinase- B (PKB) and protein phospholipase D (PLD) pathways. High C5aR expression levels have been associated with the pathogenesis of many inflammatory conditions, autoimmune and neurodegenerative diseases like rheumatoid arthritis, multiple sclerosis, atherosclerosis and inflammatory bowel disease. In vivo blockade of C5aR greatly reduces inflammatory injury. Using immunohistology there is no evidence for non-myeloid expression in healthy control rats. However, under inflammatory situations, the C5aR was found to be upregulated in various organs and tissues including the liver.Antibody R63 is directed against the amino-terminal domain Ex1 of the rat C5aR.
     

    IHC-F: 7 µm frozen paraformaldehyde fixed sections were blocked with serum and incubated with mAb at 5  µg/ml.
    FC: 3-5  µg/ml per 2x105 cells
    WB: 1/500-1000

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cell membrane, Cytoplasmic vesicle
    Post transnational modification: Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand.
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    Monoclonal Antibody to Rat C5aR (clone: R63)

    Product code: 10-3564
    *specify in mg or ml

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