Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Antibodies
  4. /
  5. TLR and Innate Immunity
  6. /
  7. Monoclonal Antibody to Human TLR4/MD-2 (Clone : 7E3)

Monoclonal Antibody to Human TLR4/MD-2 (Clone : 7E3)

Share:

Monoclonal Antibody to Human TLR4/MD-2 (Clone :  7E3)

Roll over image to zoom in

   

Product code: 10-3521

Clone name : 7E3
Clonality : Monoclonal
Application : FACS
Reactivity : Human

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   100 µg

  •  500 µg

  • $754.00 

  • $1,745.00 

Add to Wish List

Bulk Order

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • More
  • Review   (0)
Format : Purified
Amount : 500 µg
Isotype : Mouse IgG1
Content : 0.5 mg, 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin.
Storage condition : Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Gene : TLR4
Gene ID : 7099
Uniprot ID : O00206
Alternative Name : CD284 / Lymphocyte antigen 96, ESOP-1, LY96
Immunogen Information : TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein

The monoclonal antibody 10-3521 reacts with the Toll-like receptor 4 (TLR4, CD284)/MD-2 complex. TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells. The monoclonal antibody 7E3 reacts with the TLR4/MD-2 complex and is able to inhibit the biological activity of the TLR4/MD-2 complex.

Subcellular location: Cell membrane
Post transnational modification: N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
Tissue Specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
BioGrid: 112954. 31 interactions.
There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Recombinant Human Brevican Core Protein/BCAN/BEHAB (C-6His)

Recombinant Human Brevican Cor...

details-Recombinant Human Brevican Core Protein/BCAN/BEHAB (C-6His)
Anti-Human CD66e APC (Clone : CB30)

Anti-Human CD66e APC (Clone : ...

details-Anti-Human CD66e APC (Clone : CB30)
Anti-CTLA4 Antibody (ipilimumab biosimilar) (MDX-CTLA-4)

Anti-CTLA4 Antibody (ipilimuma...

details-Anti-CTLA4 Antibody (ipilimumab biosimilar) (MDX-CTLA-4)
TNFRSF25 Human

TNFRSF25 Human

details-TNFRSF25 Human
Anti-Human VEGF (Bevacizumab) – Biotin

Anti-Human VEGF (Bevacizumab) ...

details-Anti-Human VEGF (Bevacizumab) – Biotin
CRP Native Protein

CRP Native Protein

details-CRP Native Protein
Anti-Mouse CD106 PE (Clone : 429 (MVCAM.A))

Anti-Mouse CD106 PE (Clone : 4...

details-Anti-Mouse CD106 PE (Clone : 429 (MVCAM.A))
Anti-Human CD361 APC (Clone : MEM-216)

Anti-Human CD361 APC (Clone : ...

details-Anti-Human CD361 APC (Clone : MEM-216)
VEGF Rat, Yeast

VEGF Rat, Yeast

details-VEGF Rat, Yeast
PLA2G1B Recombinant Protein (C-term, His Tag)(Discontinued)

PLA2G1B Recombinant Protein (C...

details-PLA2G1B Recombinant Protein (C-term, His Tag)(Discontinued)
Anti-Human CD49D (Integrin alpha 4) (Natalizumab)

Anti-Human CD49D (Integrin alp...

details-Anti-Human CD49D (Integrin alpha 4) (Natalizumab)
Anti-Human CD172b PE (Clone : B4B6)

Anti-Human CD172b PE (Clone : ...

details-Anti-Human CD172b PE (Clone : B4B6)
Recombinant human CD43 protein with C-terminal human Fc tag

Recombinant human CD43 protein...

details-Recombinant human CD43 protein with C-terminal human Fc tag
Anti-HSP60 Monoclonal Antibody (Clone : LK1) RPE

Anti-HSP60 Monoclonal Antibody...

details-Anti-HSP60 Monoclonal Antibody (Clone : LK1) RPE

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin

Related Products

Polyclonal Antibody to NALP10

Polyclonal Antibody to NALP10

Polyclonal Antibody to TLR1

Polyclonal Antibody to TLR1

Polyclonal Antibody to TRIL

Polyclonal Antibody to TRIL

New Products

M.Pneumoniae P30

M.Pneumoniae P30

Recombinant Human CD45RA (C-6His)

Recombinant Human CD45RA (C-6His)

Recombinant Human Zinc finger protein 750(C-His)

Recombinant Human Zinc finger protein 750(C-His)

close

Please Login to write a Review !!


close

Monoclonal Antibody to Human TLR4/MD-2 (Clone : 7E3)

Product code: 10-3521
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart