Mouse Monoclonal Antibody to Human TIM-3 (Clone : TI.B2) (Discontinued)
Figure-1 : ELISA binding of TIM3 Antibody (Clone: TI.B2) with Human TIM3 recombinant protein. Coating antigen: TIM3-Fc at 0.5 µg/ml. TIM3 antibody dilution start from 1000 ng/ml, EC50= 6.98 ng/ml.
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| Format : | Purified |
| Amount : | 40 µg |
| Isotype : | Mouse IgG1, Kappa |
| Purification : | Protein A chromatography |
| Content : | 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. |
| Storage condition : | The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
TIM-3 (T cell immunoglobulin and mucin domain-3), is a member of the TIM family of immune regulating molecules. Its binding to Galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Anti-Human TIM3 Antibody (TI.B2), mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from mouse immunized with recombinant human TIM3-Fc.
ELISA detection: 0.01-0.1 µg/ml
Flow cytometry: 5-7 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Membrane, Cell junction |
| Post transnational modification: | Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9. |
| Tissue Specificity: | Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells. |
| BioGrid: | 124313. 72 interactions. |
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