PE-conjugated Anti-UPA antibody(DMC440); IgG1 Chimeric mAb
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| Amount : | 100 Test |
| Isotype : | Rabbit/Human Fc chimeric IgG1 |
| Purification : | Purified from cell culture supernatant by affinity chromatography |
| Content : | Liquid PBS�with�0.05%�Proclin300,�1%�BSA |
| Storage condition : | Store�at�2�C-8�C�for�6�months |
| Gene : | UPA |
| Uniprot ID : | P00749 |
| Alternative Name : | ATF; BDPLT5; QPD; u-PA; UPA; URK |
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants; at least one of which encodes an isoform that is proteolytically processed.
Flow Cyt 1:100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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