Polyclonal Antibody to Alpha-II spectrin (Discontinued)
Figure 1: Mixed neuron-glial cultures stained with rabbit antibody to alpha-II spectrin (green) and mouse polyclonal antibody to Nestin (red). The alpha-II spectrin antibody stains numerous axonal and dendritic profiles in these cultures, clearly revealing the submembraneous cytoskeleton. Since alpha-II spectrin is specific for neurons in the CNS, the glial cells in this culture are not recognized by this antibody.
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| Format : | Sera |
| Amount : | 100 µl |
| Isotype : | Rabbit, IgG |
| Content : | Antibody is supplied as an aliquot of serum. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Gene : | SPTAN1 |
| Gene ID : | 6709 |
| Uniprot ID : | Q13813 |
| Alternative Name : | Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit |
| Immunogen Information : | The antibody was raised against a mix of five recombinant constructs containing the entire C-terminal region of human alpha-II spectrin (amino acids 676-2,400). |
Western blot: 1:5,000-1:10,000. ICC/IF and IHC: 1:500-1:1,000 .
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Cytoplasm |
| Post transnational modification: | Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. |
| BioGrid: | 112587. 179 interactions. |
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