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    7. Polyclonal Antibody to PKC Zeta(Phospho-Thr410)

    Polyclonal Antibody to PKC Zeta(Phospho-Thr410)

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    Figure 1: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using PKC? (Phospho-Thr410) antibody (35-1283 ).

    Polyclonal Antibody to PKC Zeta(Phospho-Thr410)

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    Product code: 35-1283

    Clonality : Polyclonal
    Application : IHC
    Reactivity : Rat, Mouse, Human

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    •   50 µg

    •  100 µg

    • $337.00 

    • $400.00  $320.00 

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    • Product Info
    • Antigen Details
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    Format : Purified
    Amount : 100 µg
    Isotype : Rabbit IgG
    Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
    Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
    Gene : PRKCZ
    Gene ID : 5590
    Uniprot ID : Q05513
    Alternative Name : PKC2, PKC-ZETA
    Immunogen Information : Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3 alpha/beta.

    Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukins production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In NF-kappa-B-mediated inflammatory response, can relieve the SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Is necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells.

    Predicted MW: 78kd, Immunohistochemistry: 1:50~1:100

    For Research Use Only. Not for use in diagnostic/therapeutics procedures.

    Subcellular location: Cytoplasm
    Post transnational modification: CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase.
    Tissue Specificity: Expressed in brain, and to a lesser extent in lung, kidney and testis.
    BioGrid: 111576. 90 interactions.
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    Polyclonal Antibody to PKC Zeta(Phospho-Thr410)

    Product code: 35-1283
    *specify in mg or ml

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