Recombinant anti-human-IL-1 beta Antibody (Canakinumab)
Target: IL-1 Beta
Generic name: Canakinumab
Product Origin: Recombinant in CHO cells
Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass with a molecular mass of 145157 Daltons when deglycosylated. Canakinumab binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra).
|Purification :||Purity: >98.0% as determined by SEC-HPLC & SDS-PAGE.|
|Content :||10mM Phosphate pH-7.0, 150 mM NaCl, 20% Glycerol|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
|Amino acid sequence :||PepMap Analysis of N terminal amino acids sequence : H chain: QVQLVESGGG, L chain: EIVLTQSPDFQS|
Specificity: Human IL1 beta. Does not cross react with other members of the interleukin-1 family.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.