Recombinant human CCR3 protein with C-terminal human Fc tag
|Amount :||100 µg|
|Purification :||The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.|
|Content :||Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.|
|Storage condition :||Store at -80°C for 12 months (Avoid repeated freezing and thawing)|
|Alternative Name :||CC-CKR-3; CD193; CKR3; CMKBR3|
The protein has a predicted molecular mass of 29.26 kDa after removal of the signal peptide.
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.