Recombinant Human IL-23R Domain1 (C-hFc)
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| AA sequence : | Gly24-Tyr123 |
| Uniprot ID : | Q5VWK5-1 |
| Alternative Name : | IL23R,IL-23 Receptor |
Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
