Recombinant Human IL-4
|Alternative Name :||BCGF, BCDF, B cell stimulating factor (BSF-1)|
|Amount :||20 µg|
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
|Purification :||Purity: >= 98% by SDS-PAGE gel and HPLC analyses.|
|Content :||This recombinant protein is supplied in lyophilized form.|
|Storage condition :||Lyophilized: -20oC to -80oC Reconstituted: 2oC to 8oC for one week|
|Amino acid sequence :||MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS|
The ED50 as determined by the dose-dependent stimulation of human TF-1 cells is <= 0.2 ng/ml, corresponding to a specific activity of >= 5 x 106 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.