Animal-Free Recombinant Human IL-1Beta
|Amount :||10 µg in 50 ul sterile PBS|
|Purification :||Purity: >= 98% by SDS-PAGE gel and HPLC analyses.|
|Content :||This recombinant protein is supplied in liquid form.|
|AA sequence :||APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS|
|Alternative Name :||Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)|
IL-1Beta is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1Alpha and IL-1Beta bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1Beta is a secreted cytokine, IL-1Alpha is predominantly a cell-associated cytokine. Recombinant Human IL-1Beta is a 17.3 kDa protein containing 153 amino acid residues.
Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is <= 0.001 ng/ml, corresponding to a specific activity of >= 1 x 109units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.