anti-ACE2, mAb (Clone: AC18F) (ATTO 488)
|Amount :||100 tests|
|Isotype :||Mouse IgG1,k|
|Purification :||Protein G-affinity purified.|
|Content :||Liquid. In PBS.
|Storage condition :||Short Term Storage : 4°C ; Long Term Storage 4°C ;Do not freeze. Protect from light.|
|Uniprot ID :||Q9BYF1|
|Alternative Name :||SARS Receptor; Angiotensin-converting Enzyme 2; ACEH; Metalloprotease MPROT15; SARS-CoV-2 Receptor, SARS, SARS-CoV, SARS-CoV-2|
|Immunogen Information :||Recombinant human ACE2.|
Specificity : Recognizes human ACE2.
Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.
Flow Cytometry: (1:1'000)
Optimal conditions should be determined individually for each application.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.