Anti-CD11b / Mac-1 alpha Monoclonal Antibody (Clone:MEM-174)-APC Conjugated
|Amount :||100 tests|
|Isotype :||Mouse IgG2a|
|Storage condition :||Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.|
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
|Subcellular location:||Cell membrane, Membrane raft|
|Tissue Specificity:||Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).|
|BioGrid:||109890. 10 interactions.|