Fig. 1: Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with CD137L-Monospecific Mouse Monoclonal Antibody (CD137L/1547).
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Product code: 36-3431
| Clone name : | CD137L/1547 |
| Application : | FACS, IHC |
| Reactivity : | Human |
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| Gene : | TNFSF9 |
| Gene ID : | 8744 |
| Uniprot ID : | P41273 |
| Alternative Name : | 4-1BB ligand; 4-1BBL; CD137L; ILA ligand (TNF related); Ly63l; Tumor necrosis factor ligand 5A (TNLG5A); Tumor necrosis factor ligand superfamily member 9 (TNFSF9) |
| Amount : | 100 µg |
| Isotype : | Mouse IgG2a, kappa |
| Immunogen Information : | Recombinant full-length human CD137L protein |
TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thoµght to be involved in T cell-tumor cell interaction.
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
Flow Cytometry (1-2µg/million cells in 0.1ml); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
