Anti-CD14 / LPS-receptor Monoclonal Antibody (Clone:MEM-18)

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Product code: 30-1118

Clone name :	MEM-18
Clonality :	Monoclonal
Application :	FACS
Reactivity :	Non-Human Primates

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Format :	Purified
Amount :	0.1 mg
Isotype :	Mouse IgG1
Purification :	Purified by protein-A affinity chromatography
Storage condition :	Store at 2-8°C. Do not freeze.


Gene :	CD14
Gene ID :	929
Uniprot ID :	P08571
Alternative Name :	CD14
Immunogen Information :	A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.

The antibody MEM-18 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol)-linked extracellular membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages. In human, the epitope recognized by MEM-18 is located between amino acids 57-64.

Flow Cytometry Recommended dilution:4 µg/ml
Immunoprecipitation Western Blotting ELISA The antibody MEM-18 has been tested as the detection antibody in a sandwich ELISA for analysis of human CD14 in combination with antibody B-A8 . Functional Application The antibody MEM-18 completely blocks binding of fluorescein (FITC) - labeled bacterial LPS to the monocyte surface and it also blocks the binding of CD14 to the extracellular TLR2 domain.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane, Secreted, Membrane raft, Golgi apparatus
Post transnational modification:	N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Tissue Specificity:	Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
BioGrid:	107367. 35 interactions.