Anti-CD154 / CD40L Monoclonal Antibody (Clone: 24-31) Biotin Conjugated
Figure 1: Flow cytometry surface staining pattern of human stimulated (PMA+Ionomycin) peripheral blood mononuclear cells stained using anti-human CD154 (24-31) biotin antibody (concentration in sample 1.67 μg/ml, Streptavidin APC).
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
| Content : | Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Specificity: The mouse monoclonal antibody 24-31 detects an extracellular epitope of CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.
Description: CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.
Flow cytometry: Recommended dilution: 1-5 μg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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