Anti-CD161 Monoclonal Antibody (Clone:10/78)-PE Conjugated
|Amount :||0.1 mg|
|Isotype :||Mouse IgG1|
|Storage condition :||Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.|
CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
|Tissue Specificity:||Expressed in a subset of natural killer cells.|