Anti-CD38 antibody(DM28), Rabbit mAb
Figure 1. Expi 293 cell line transfected with irrelevant protein (left) and human CD38 (right) were surface stained with Rabbit anti-CD38 monoclonal antibody 1µg/ml (clone: DM28) followed by Alexa 488-conjugated anti-rabbit IgG secondary antibody.
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| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from cell culture supernatant by affinity chromatography |
| Storage condition : | Store at -20°C for 12 months (Avoid repeated freezing and thawing) |
| Alternative Name : | T10, cADPr hydrolase 1 |
| Immunogen Information : | Recombinant human CD38 (Val43-IIe300) produced by using human HEK293 cells |
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
Recommended Dilutions ELISA 1/5000-10000; FACS 1/100
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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