Anti-CD81 Monoclonal Antibody (Clone:M38)-Low Endotoxin
|Format :||Low Endotoxin|
|Amount :||0.1 mg|
|Isotype :||Mouse IgG1|
|Purification :||Purified by protein-A affinity chromatography|
|Storage condition :||Store at 2-8°C. Do not freeze.|
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
Functional application: In human MOLT-4 T-cell line the antibody M38 inhibits syncytium formation induced by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines.
Flow cytometry: recommended dilution: 1 μg/ml.
Western blotting: recommended dilution: 1-2 μg/ml; positive control: Jurkat cells, non-reducing conditions.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Basolateral cell membrane|
|Post transnational modification:||Not glycosylated.|
|Tissue Specificity:||Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.|
|BioGrid:||107413. 201 interactions.|