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  7. Anti-LAT Monoclonal Antibody (Clone:LAT-01)

Anti-LAT Monoclonal Antibody (Clone:LAT-01)

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Figure 1: Flow Cytometry analysis of LAT expression in peripheral blood lymphocytes using anti-human LAT (LAT-01) (surface markers were stained prior to intracellular staining of human LAT).Panel A: gate on CD4+ cells , Panel B: gate on CD8+ cells

Anti-LAT Monoclonal Antibody (Clone:LAT-01)

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Product code: 30-1236

Clone name : LAT-01
Clonality : Monoclonal
Application : WB
Reactivity : Human

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0.1 mg
$365.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : LAT
Gene ID : 27040
Uniprot ID : O43561
Alternative Name : Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, p36-38
Immunogen Information : Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.

Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized.
Flow cytometry: Intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized.
Western blotting: Recommended dilution: 1-2 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Post transnational modification: Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
Tissue Specificity: Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
BioGrid: 117971. 41 interactions.
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Anti-LAT Monoclonal Antibody (Clone:LAT-01)

Product code: 30-1236
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