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  7. Anti-MDR3 Monoclonal Antibody (Clone:IHC621)

Anti-MDR3 Monoclonal Antibody (Clone:IHC621)

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Figure 1: Immunohistochemical analysis of MDR3 (IHC621) on Liver

Anti-MDR3 Monoclonal Antibody (Clone:IHC621)

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Product code: 44-1165

Clone name : IHC621
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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  •  1 ml

  • $475.00 

  • $1,438.00 

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  • Antigen Details
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Format : Purified
Amount : 1 ml
Purification : Protein A/G Chromatography
Storage condition : Store at 2°C - 8°C.
Gene : ABCB4
Gene ID : 5244
Uniprot ID : P21439
Alternative Name : Phosphatidylcholine translocator ABCB4, ATP-binding cassette sub-family B member 4, Multidrug resistance protein 3, P-glycoprotein 3

Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-MDR3 Monoclonal Antibody (Clone:IHC621)

Product code: 44-1165
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