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  7. Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)

Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)

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Figure 1: Immunohistochemical analysis of PD-L1 (Clone: IHC411) on Lung

Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)

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Product code: 44-1069

Clone name : IHC411
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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  •   0.1 ml

  •  0.5 ml

  • $275.00 

  • $500.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Rabbit IgG
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : CD274
Gene ID : 29126
Uniprot ID : Q9NZQ7
Immunogen Information : Recombinant Human PD-L1

"Programmed Death-Ligand 1 (PD-L1), also known as CD274 or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumor cells resistant to CD8+ T cell-mediated lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumor aggressiveness and risk of death, and, in ovarian cancer, higher expression of this protein has lead to significantly poorer prognosis. PD-L1 has also been linked to systemic lupus erythematosus and cutaneous melanoma. When considered in adjunct with CD8+ tumor-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma."

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Endomembrane system
Post transnational modification: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
BioGrid: 118891. 48 interactions.
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Anti-PD-L1 Rabbit Monoclonal Antibody (Clone:IHC411)

Product code: 44-1069
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