Anti-TCF7/TCF1 Polyclonal Antibody(Discontinued)
|Amount :||100 µg|
|Isotype :||Rabbit IgG|
|Purification :||Protein A|
|Content :||PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
WB (1:1000); IHC (1:50); optimal dilutions for assays should be determined by the user.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.