Anti-Topoisomerase II alpha (Proliferation & Drµg-Resistance Marker) Monoclonal Antibody(Clone: TOP2A/1362)
Fig. 1: Formalin-fixed, paraffin-embedded human Tonsil stained with Topoisomerase II alpha Monoclonal Antibody (TOP2A/1362).
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2b, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | TOP2A |
| Gene ID : | 7153 |
| Uniprot ID : | P11388 |
| Alternative Name : | ATP hydrolyzing DNA topoisomerase II alfa; DNA gyrase; DNA topoisomerase (ATP hydrolyzing); DNA topoisomerase 2 alpha; DNA topoisomerase II 170kD; DNA topoisomerase II alpha; DNA Topoisomerase2; TOP2A; Topoisomerase DNA II alpha 170kDa; TP2A |
| Immunogen Information : | Recombinant fragment of human Topoisomerase II alpha (around aa1352-1493) (exact sequence is proprietary) |
It recognizes a 170kDa protein, which is identified as topoisomerase II is also implicated in drµg resistance of tumor cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topo IIa is the predominant mechanism of resistance to several chemotherapeutic agents.
Western Blot (0.5-2µg/ml); Immunofluorescence (1-2µg/ml); Immunohistochemistry (Formalin-fixed) (0.5-1µg/ml for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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