Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Other Kits
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Recombinant Proteins
  4. /
  5. C1q Native Protein

C1q Native Protein

Share:

C1q Native Protein

Roll over image to zoom in

   

Product code: 32-3372

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS / Manual
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   200ug

  •  1 mg

  • $494.00 

  • $956.00 

Add to Wish List

Bulk Order

Shipping Info:

For estimated delivery dates, please contact us at support@abeomics.com

Download TDS / Manual

  • Product Info
  • Description
  • Review   (0)
Amount : 1 mg
Purification : Greater than 96.0%.
Content : In sterile filtered 10 mM HEPES and 300mM NaCl, pH 7.2. Concentration is lot dependent.
Storage condition : Human C1q is stable at 4°C if entire vial will be used within 2-4 weeks. Store, frozen below -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Alternative Name : Component C1q, Complement C1q, Complement Component C1q, C1q.

Source : Human Plasma. Human Complement Component C1q produced in Human plasma having a molecular mass of 410 kDa. C1q is the first component of the classical pathway of complement activation. C1q along with the enzymatically active components C1r and C1s forms the C1 complex. When C1 binds to immunoglobulins in the form of immune complexes, it leads to activation of C1r and C1s proteases and a further activates the classical pathway of complement. C1q is a glycoprotein that belongs to the collectin family, having a molecular weight of about 410-462 kDa. C1q is a hexamer composed of globular heads attached to collagen-like triple-helix tails. The globular heads of C1q exclusively bind to the CH2 domain of IgG molecules or the CH3 domain of IgM. Each heavy chain of the immunoglobulin molecule contains a single binding site for C1q. Given that C1q must bind to no less than two heavy chains in order to alter its conformation and activate C1r and C1s, its activation follows only after binding to immunoglobulins in the form of immune complexes bound to multivalent antigens. C1q's main physiological role is in the clearance of immune complexes and apoptotic bodies from the organism. Interruption of this process may lead to development of autoimmunity. Individuals with genetic deficiencies of C1q or other components of the classical pathway are at risk to develop SLE. C1q specifically binds to apoptotic bodies of human keratinocytes, vascular endothelial cells and lymphocytes. Complement components C1q and bound C3 mediate the clearance of apoptotic bodies. Hence, C1q may advance the clearance of autoantigens, avoiding stimulation of the immune system. Nonetheless, an extended exposition of the immune system to the neoepitope exposed on C1q molecules bound to immune complexes or apoptotic bodies could ultimately lead to an autoimmune response against C1q itself and to an altered complement function. C1q deficiency may also lead to disruption of the negative selection of autoreactive B cells. C1q along with other specific recognition proteins bind to the highly conserved lupus antigens (dsDNA and nuclear proteins) and activate the complement system. Autoantibodies against C1q (anti-C1q) are found in a number of autoimmune and infectious diseases like glomerulonephritis (GN) and lupus erythematosus (SLE), these antibodies are significant in clinical practice due to their negative predictive value.

There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Anti-CD123 antibody(DM31), Rabbit mAb

Anti-CD123 antibody(DM31), Rab...

details-Anti-CD123 antibody(DM31), Rabbit mAb
Recombinant human GPC1 protein with C-terminal human Fc tag

Recombinant human GPC1 protein...

details-Recombinant human GPC1 protein with C-terminal human Fc tag
Anti-CD22 antibody(DM14), Rabbit mAb

Anti-CD22 antibody(DM14), Rabb...

details-Anti-CD22 antibody(DM14), Rabbit mAb
Anti-IL2RA Antibody (basiliximab biosimilar) (CHI621)

Anti-IL2RA Antibody (basilixim...

details-Anti-IL2RA Antibody (basiliximab biosimilar) (CHI621)
Recombinant Human Hepatitis A Virus Cellular Receptor 1

Recombinant Human Hepatitis A ...

details-Recombinant Human Hepatitis A Virus Cellular Receptor 1
Anti-Human IL-6 (Sarilumab) – Biotin

Anti-Human IL-6 (Sarilumab) –...

details-Anti-Human IL-6 (Sarilumab) – Biotin
Anti-beta-Actin Monoclonal Antibody (Clone: AC-15)

Anti-beta-Actin Monoclonal Ant...

details-Anti-beta-Actin Monoclonal Antibody (Clone: AC-15)
Anti-DLL4 PE (Clone : MHD4-46)

Anti-DLL4 PE (Clone : MHD4-46)

details-Anti-DLL4 PE (Clone : MHD4-46)
Cyclophilin B His Recombinant Protein

Cyclophilin B His Recombinant ...

details-Cyclophilin B His Recombinant Protein
Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)

Anti-CDX-2 Monoclonal Antibody...

details-Anti-CDX-2 Monoclonal Antibody (Clone:IHC402)
Anti-SARS-CoV-2 Spike antibody(DM42), Rabbit mAb

Anti-SARS-CoV-2 Spike antibody...

details-Anti-SARS-CoV-2 Spike antibody(DM42), Rabbit mAb
Anti-MSH2 Monoclonal Antibody (Clone:IHC410)-Ready to Use

Anti-MSH2 Monoclonal Antibody ...

details-Anti-MSH2 Monoclonal Antibody (Clone:IHC410)-Ready to Use
Anti-beta-Galactosidase Monoclonal Antibody (Clone:BG-02)

Anti-beta-Galactosidase Monocl...

details-Anti-beta-Galactosidase Monoclonal Antibody (Clone:BG-02)
Recombinant Human Retinoic Acid Receptor Responder 2

Recombinant Human Retinoic Aci...

details-Recombinant Human Retinoic Acid Receptor Responder 2

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin

Related Products

Influenza B Virus Florida 04/06

Influenza B Virus Florida 04/06

Recombinant Human Parathyroid Hormone 1 Receptor/PTH1R (Gly49, C-6His)

Recombinant Human Parathyroid Hormone 1 Receptor/PTH1R (Gly49, C-6His)

TPMT Recombinant Protein

TPMT Recombinant Protein

New Products

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Anti-IL-23 (Tremfya)(Guselkumab biosimilar) mAb

Recombinant TLR9 Protein with human Fc Tag

Recombinant TLR9 Protein with human Fc Tag

Recombinant human TLR3 protein with C-terminal mouse Fc tag

Recombinant human TLR3 protein with C-terminal mouse Fc tag

close

Please Login to write a Review !!


close

C1q Native Protein

Product code: 32-3372
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart