Coronavirus (COVID-19) Spike Receptor Binding Domain (300-600 a.a.)
|Purification :||CoV 2019 Spike Receptor Binding Domain Protein is >90% pure as determined SDS-PAGE.|
|Content :||CoV 2019 Spike Receptor Binding Domain Protein 1mg/ml solution is supplied in 1x PBS.|
|Storage condition :||Store at -20°C.|
SOURCE : Escherichia Coli ;
PHYSICAL APPEARANCE : Sterile Filtered clear solution ;
The E.Coli derived recombinant protein contains the Coronavirus 2019 Spike Receptor Binding Domain (300-600 a.a.) immunodominant region, fused to His tag at C-terminal. A human infecting coronavirus (viral pneumonia) called 2019 novel coronavirus, 2019-nCoV was found in the fish market at the city of Wuhan, Hubei province of China on December 2019. The 2019-nCoV shares an 87% identity to the 2 bat-derived severe acute respiratory syndrome 2018 SARS-CoV-2 located in Zhoushan of eastern China. 2019-nCoV has an analogous receptor-BD-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the 2019-nCoV might bind to ACE2 receptor protein (angiotensin-converting enzyme 2) in humans. While bats are possibly the host of 2019-nCoV, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the 2019-nCoV is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus.