CpG ODN (2006), TLR9 ligand (Class B)
|Amount :||0.1 mg|
|Content :||1 mg/ml in endotoxin-free water|
|Storage condition :||Upon receipt, store at -20°C (Stable for at least 6 months). Avoid frequent freeze/thaw cycles.|
Synthetic oligodeoxynucleotides (ODN) containing unmethylated deoxycytosine-deoxyguanosine (CpG) motif are equivalent to bacterial DNA in the immunostimulatory activity, which can induce innate immunity via Toll-like receptor 9 (TLR9) in mammals. There are three major classes of CpG ODNs, and each ODN class exhibits different stimulatory effects on immune cell activation. Class A ODNs are potent inducers of IFN-alpha that leads to the plasmacytoid dendritc cell (pDC) maturation. Class B ODNs are relatively weak inducers of type I IFNs but strong stimulators of human B cells and monocyte maturation. Class C ODNs combine elements of both Classes A and B ODNs, which can induce IFN-alpha in pDC and activation of B cells.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.